Evaluation of the intervention of autonomic nervous system in mediating the inhibitory effect of NaHS on stimulated-gastric acid secretion in rats

AUTHORS

Seyyed Ali Mard , *

How to Cite: Mard S A. Evaluation of the intervention of autonomic nervous system in mediating the inhibitory effect of NaHS on stimulated-gastric acid secretion in rats , Jentashapir J Health Res. Online ahead of Print ; 3(1):257-266.

ARTICLE INFORMATION

Jentashapir Journal of Health Research: 3 (1); 257-266
Published Online: June 30, 2011
Article Type: Research Article
Received: January 1, 1970
Accepted: March 9, 2012

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Many studies have shown that H2S protects the gastric mucosa on different models of stress but till now there are few studies about the effects of H2S on gastric acid secretion. Therefore, the aim of the present study was to investigate the role of autonomic nervous system in mediating the inhibitory effect of hydrogen sulfide donor (NaHS) on stimulated gastric acid secretion in rats.

Material and methods: Fifty-six male Wistar rats (180-220gr) were randomly divided into 7 groups (8 in each). To gastric catheterization and measurement the gastric acid output, animals underwent a midline laparatomy under a mixture of ketamine and xylasine anesthesia. When the stimulated gastric acid output was relatively constant for thirty min in response to carbachol and pentagastrin, animals received NaHS (80 g/kg,i.v).To determine the role of autonomic nervous system in mediating the inhibitory effect of NaHS on gastric acid secretion, two groups of animals underwent vagotomy or reserpination.

Results: NaHS decreased carbachol-induced gastric acid secretion (p<0.05). The inhibitory effect of NaHS on gastric acid secretion in vagotomized rats was higher than in reserpinized rats.

Keywords

© 2011, School of Medicine, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: