Study the effects of malva sylvestris hydro-alcoholic extract onThecarrageenan-induced inflammation in male rat paw


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How to Cite: Study the effects of malva sylvestris hydro-alcoholic extract onThecarrageenan-induced inflammation in male rat paw, Jentashapir J Cell Mol Biol. Online ahead of Print ; 4(1):1-10.


Jentashapir Journal of Health Research: 4 (1); 1-10
Published Online: June 30, 2014
Article Type: Research Article
Received: June 23, 2012
Accepted: December 7, 2012




Background: Using chemical drugs have often masses of damaged side effects Therefore,it is important to research about medicinal plants with anti-inflammation and fewer side effects.malvasylvestris has potential use as a medicinal plant. The aim of this study was to investigate the effect of Malva Sylvestris flowers hydroalcoholic extract on the carrageennan-induced inflammatory response using Wistar male rats' paws

Material and methods: Malva Sylvestris flowers powder wasmacerated with 70%ethanol, and its extract prepared. Male Wistar rats were divided into 6 groups of 10 animals each for following treatments: Malva extract (200,400,600 and 800 mg/kg), normal saline (5mg/kg) as negative control and Aspirin (300mg/kg) as a positive via IP.Thirty min later inflammation was induced by injection of 100lcarrageenan (1%W/V) into the rat's hind paw of rats(SC). The inflamation response changes were inspected over 5 hours every hour, using plethysmometer.

Results: The extract-treated (600,800 mg/kg) showed considerable reduction in the rats' paws inflamation when compared with control groop(p>0.05). But 200 and 400 mg/kg extract showed no considerable decrease in inflamation when comparied with control group (p<0.05). There was not significant differences between doses of 600 and 800 mg/kg of extract, therfore dose of 600 mg/kg was selected as the most favorable dose as anti-inflamation.


© 2014, School of Medicine, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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