Effect of Fumaria Parviflora hydro alcoholic extract on induced carageenan inflammation in male rat paw

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How to Cite: Effect of Fumaria Parviflora hydro alcoholic extract on induced carageenan inflammation in male rat paw, Jentashapir J Cell Mol Biol. Online ahead of Print ; 4(2):121-130.

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Jentashapir Journal of Health Research: 4 (2); 121-130
Published Online: June 30, 2013
Article Type: Research Article
Received: June 10, 2012
Accepted: September 16, 2012

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Abstract

Background: This study investigated the anti-inflammatory effect of Fumaria Parviflora due to its Fumaric acid, flavonoid and phenolic compounds for skin diseases, relieves itching and eczema.

Material and methods: Male wistar rats (ranging 150-180g in weight) were used. For preparation of the hydro alcoholic extract, Plant powdered were macerated in ethanol 70%, then extract were concentrated for further use. Five treatment Animal groups received dose of 200, 400, 600, 800 or 1000 mg/kg of Fumaria Parviflora extract, Positive control group received a dose of 300 mg/kg aspirin and negative control group received serum physiology solution with dose of 5 ml/kg via intra-peritoneal injection of traits. After half an hour, 100 micro liters of carageenan 1%was subcutaneously injected into the rats paw and then the volume of the rats paws were evaluated using PLethysmometer apparatus.once every hours between the first and fifth hours

Results: 200 and 400 mg/kg doses of extract had less effect on decreasing the paws edema in comparison with animal group received aspirin (p<0.05). However, dose of 600, 800 and 1000 mg/kg of the extract had more effects on decreasing the paws edema, but difference between two groups is not statistically significant (p>0.05).

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© 2013, School of Medicine, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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