Jentashapir Journal of Health Research

Published by: Kowsar

The Ambiguous Role of Treg Cells in Mycobacterium tuberculosis Pathogenesis

Masoud Keikha ORCID 1 , 2 , *
Author Information
1 Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Article information
  • Jentashapir Journal of Health Research: October 31, 2018, 9 (5); e83541
  • Published Online: December 16, 2018
  • Article Type: Letter
  • Received: August 22, 2018
  • Accepted: September 10, 2018
  • DOI: 10.5812/jjhs.83541

To Cite: Keikha M. The Ambiguous Role of Treg Cells in Mycobacterium tuberculosis Pathogenesis, Jentashapir J Health Res. 2018 ; 9(5):e83541. doi: 10.5812/jjhs.83541.

Copyright © 2018, Jentashapir Journal of Health Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. World Health Organization. World malaria report 2015. WHO; 2016.
  • 2. Jasmer RM, Nahid P, Hopewell PC. Clinical practice. Latent tuberculosis infection. N Engl J Med. 2002;347(23):1860-6. doi: 10.1056/NEJMcp021045. [PubMed: 12466511].
  • 3. Ghazalsofala R, Rezaee SA, Rafatpanah H, Vakili R, Ghazvini K, Heidarnejad F, et al. Evaluation of CD4+ CD25+ FoxP3+ regulatory T cells and FoxP3 and CTLA-4 gene expression in patients with newly diagnosed tuberculosis in northeast of Iran. Jundishapur J Microbiol. 2015;8(4). e17726. doi: 10.5812/jjm.8(4)2015.17726. [PubMed: 26034548]. [PubMed Central: PMC4449857].
  • 4. Karbalaei Zadeh Babaki M, Soleimanpour S, Rezaee SA. Antigen 85 complex as a powerful Mycobacterium tuberculosis immunogene: Biology, immune-pathogenicity, applications in diagnosis, and vaccine design. Microb Pathog. 2017;112:20-9. doi: 10.1016/j.micpath.2017.08.040. [PubMed: 28942172].
  • 5. Lienhardt C, Azzurri A, Amedei A, Fielding K, Sillah J, Sow OY, et al. Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo. Eur J Immunol. 2002;32(6):1605-13. doi: 10.1002/1521-4141(200206)32:6<1605::AID-IMMU1605>3.0.CO;2-6. [PubMed: 12115643].
  • 6. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol. 2008;8(7):523-32. doi: 10.1038/nri2343. [PubMed: 18566595]. [PubMed Central: PMC2665249].
  • 7. Tamura C, Nakazawa M, Kasahara M, Hotta C, Yoshinari M, Sato F, et al. Impaired function of dendritic cells in alymphoplasia (aly/aly) mice for expansion of CD25+CD4+ regulatory T cells. Autoimmunity. 2006;39(6):445-53. doi: 10.1080/08916930600833390. [PubMed: 17060023].
  • 8. Shafiani S, Tucker-Heard G, Kariyone A, Takatsu K, Urdahl KB. Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J Exp Med. 2010;207(7):1409-20. doi: 10.1084/jem.20091885. [PubMed: 20547826]. [PubMed Central: PMC2901066].
  • 9. Hougardy JM, Place S, Hildebrand M, Drowart A, Debrie AS, Locht C, et al. Regulatory T cells depress immune responses to protective antigens in active tuberculosis. Am J Respir Crit Care Med. 2007;176(4):409-16. doi: 10.1164/rccm.200701-084OC. [PubMed: 17541018].
  • 10. Hanekom WA. The immune response to BCG vaccination of newborns. Ann N Y Acad Sci. 2005;1062:69-78. doi: 10.1196/annals.1358.010. [PubMed: 16461790].
  • 11. He XY, Xiao L, Chen HB, Hao J, Li J, Wang YJ, et al. T regulatory cells and Th1/Th2 cytokines in peripheral blood from tuberculosis patients. Eur J Clin Microbiol Infect Dis. 2010;29(6):643-50. doi: 10.1007/s10096-010-0908-0. [PubMed: 20306324].
  • 12. Sharma PK, Saha PK, Singh A, Sharma SK, Ghosh B, Mitra DK. FoxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis. Am J Respir Crit Care Med. 2009;179(11):1061-70. doi: 10.1164/rccm.200804-529OC. [PubMed: 19246720].
  • 13. Chiacchio T, Casetti R, Butera O, Vanini V, Carrara S, Girardi E, et al. Characterization of regulatory T cells identified as CD4(+)CD25(high)CD39(+) in patients with active tuberculosis. Clin Exp Immunol. 2009;156(3):463-70. doi: 10.1111/j.1365-2249.2009.03908.x. [PubMed: 19438599]. [PubMed Central: PMC2691975].
  • 14. Burl S, Hill PC, Jeffries DJ, Holland MJ, Fox A, Lugos MD, et al. FOXP3 gene expression in a tuberculosis case contact study. Clin Exp Immunol. 2007;149(1):117-22. doi: 10.1111/j.1365-2249.2007.03399.x. [PubMed: 17465993]. [PubMed Central: PMC1942016].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments