Selection of suitable suspending agent for preparation of liquid oral dosage form using ion-exchange resin

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How to Cite: Selection of suitable suspending agent for preparation of liquid oral dosage form using ion-exchange resin, Jentashapir J Health Res. Online ahead of Print ; 3(3):453-458.

ARTICLE INFORMATION

Jentashapir Journal of Health Research: 3 (3); 453-458
Published Online: June 30, 2012
Article Type: Research Article
Received: June 5, 2012
Accepted: May 21, 2012

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Abstract

Background: The goal of this study was the selection of a suitable suspending agent to prepare a stable oral suspension for drug delivery by ion-exchange resins. Suspending agents are used to increase the viscosity of the media to maintain uniform dispersion during storage.

Material and methods: To select the best suspending agent, some formulations with different concentration of HEC, xanthan gum and HPMC were prepared and evaluated for physicochemical characteristics such as sedimentation volume and redispersibility.

Results: Prepared suspensions by HEC and HPMC as suspending agents in low concentrations had low sedimentation volumes and increasing in concentration caused to enhance in sedimentation volume but the redispersibility was difficult. The prepared suspensions using xanthan gum have good sedimentation volume and redispersibility.

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© 2012, Jentashapir Journal of Health Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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