Jentashapir Journal of Health Research

Published by: Kowsar

Alteration Effect of Exendin-4 on Oxidative Stress and Metabolic Disorders Induced by Bisphenol A in Adult Male Mice

Akram Ahangarpour 1 , Golshan Afshari 2 , * , Seyyed Ali Mard 3 , Ali Khodadadi 4 and Mahmoud Hashemitabar 5
Authors Information
1 Department of Physiology, Cellular and Molecular Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Physiology Research Center, Research Center for Infectious Diseases of Digestive System, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
4 Department of Immunology, Cellular and Molecular Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
5 Department of Anatomical Sciences, Cellular and Molecular Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jentashapir Journal of Health Research: October 01, 2016, 7 (5); e37836
  • Published Online: September 21, 2016
  • Article Type: Research Article
  • Received: March 14, 2016
  • Accepted: August 16, 2016
  • DOI: 10.17795/jjhr-37836

To Cite: Ahangarpour A, Afshari G, Mard S A, Khodadadi A, Hashemitabar M. Alteration Effect of Exendin-4 on Oxidative Stress and Metabolic Disorders Induced by Bisphenol A in Adult Male Mice, Jentashapir J Health Res. 2016 ; 7(5):e37836. doi: 10.17795/jjhr-37836.

Copyright © 2016, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Ahangarpour A, Zamaneh HT, Jabari A, Nia HM, Heidari H. Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats. Iran J Basic Med Sci. 2014; 17(10): 808-14[PubMed]
  • 2. Song L, Xia W, Zhou Z, Li Y, Lin Y, Wei J, et al. Low-level phenolic estrogen pollutants impair islet morphology and beta-cell function in isolated rat islets. J Endocrinol. 2012; 215(2): 303-11[DOI][PubMed]
  • 3. Alonso-Magdalena P, Quesada I, Nadal A. Endocrine disruptors in the etiology of type 2 diabetes mellitus. Nat Rev Endocrinol. 2011; 7(6): 346-53[DOI][PubMed]
  • 4. Nadal A, Alonso-Magdalena P, Ripoll C, Fuentes E. Disentangling the molecular mechanisms of action of endogenous and environmental estrogens. Pflugers Arch. 2005; 449(4): 335-43[DOI][PubMed]
  • 5. Aarab N, Lemaire-Gony S, Unruh E, Hansen PD, Larsen BK, Andersen OK, et al. Preliminary study of responses in mussel (Mytilus edilus) exposed to bisphenol A, diallyl phthalate and tetrabromodiphenyl ether. Aquat Toxicol. 2006; 78 Suppl 1-92[DOI][PubMed]
  • 6. Alonso-Magdalena P, Ropero AB, Carrera MP, Cederroth CR, Baquie M, Gauthier BR, et al. Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS One. 2008; 3(4)[DOI][PubMed]
  • 7. Sabanayagam C, Teppala S, Shankar A. Relationship between urinary bisphenol A levels and prediabetes among subjects free of diabetes. Acta Diabetol. 2013; 50(4): 625-31[DOI][PubMed]
  • 8. Mileva G, Baker SL, Konkle AT, Bielajew C. Bisphenol-A: epigenetic reprogramming and effects on reproduction and behavior. Int J Environ Res Public Health. 2014; 11(7): 7537-61[DOI][PubMed]
  • 9. Greig NH, Holloway HW, De Ore KA, Jani D, Wang Y, Zhou J, et al. Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Diabetologia. 1999; 42(1): 45-50[DOI][PubMed]
  • 10. Nielsen LL, Young AA, Parkes DG. Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regul Pept. 2004; 117(2): 77-88[PubMed]
  • 11. Young AA. 14. Glucagon-like peptide-1, exendin and insulin sensitivity. Insulin Resist Insulin Resist Syndrome. 2002; 5: 235
  • 12. Parkes DG, Pittner R, Jodka C, Smith P, Young A. Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro. Metabolism. 2001; 50(5): 583-9[DOI][PubMed]
  • 13. Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes. 2000; 49(11): 1751-60[PubMed]
  • 14. Sun F, Chai S, Li L, Yu K, Yang Z, Wu S, et al. Effects of glucagon-like peptide-1 receptor agonists on weight loss in patients with type 2 diabetes: a systematic review and network meta-analysis. J Diabetes Res. 2015; 2015: 157201[DOI][PubMed]
  • 15. Adachi T, Yasuda K, Mori C, Yoshinaga M, Aoki N, Tsujimoto G, et al. Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors. Food Chem Toxicol. 2005; 43(5): 713-9[DOI][PubMed]
  • 16. Alonso-Magdalena P, Morimoto S, Ripoll C, Fuentes E, Nadal A. The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance. Environ Health Perspect. 2006; 114(1): 106-12[PubMed]
  • 17. Bodin J, Bolling AK, Samuelsen M, Becher R, Lovik M, Nygaard UC. Long-term bisphenol A exposure accelerates insulitis development in diabetes-prone NOD mice. Immunopharmacol Immunotoxicol. 2013; 35(3): 349-58[DOI][PubMed]
  • 18. Batista TM, Alonso-Magdalena P, Vieira E, Amaral ME, Cederroth CR, Nef S, et al. Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice. PLoS One. 2012; 7(3)[DOI][PubMed]
  • 19. Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, et al. Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect. 2009; 117(10): 1549-55[DOI][PubMed]
  • 20. Moghaddam HS, Samarghandian S, Farkhondeh T. Effect of bisphenol A on blood glucose, lipid profile and oxidative stress indices in adult male mice. Toxicol Mech Methods. 2015; 25(7): 507-13[DOI][PubMed]
  • 21. Rubin BS, Soto AM. Bisphenol A: Perinatal exposure and body weight. Mol Cell Endocrinol. 2009; 304(1-2): 55-62[DOI][PubMed]
  • 22. Liu J, Yu P, Qian W, Li Y, Zhao J, Huan F, et al. Perinatal bisphenol A exposure and adult glucose homeostasis: identifying critical windows of exposure. PLoS One. 2013; 8(5)[DOI][PubMed]
  • 23. Raab EL, Vuguin PM, Stoffers DA, Simmons RA. Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats. Am J Physiol Regul Integr Comp Physiol. 2009; 297(6)-94[DOI][PubMed]
  • 24. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R. Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett. 2001; 507(2): 142-6[PubMed]
  • 25. Kim Chung le T, Hosaka T, Yoshida M, Harada N, Sakaue H, Sakai T, et al. Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression. Biochem Biophys Res Commun. 2009; 390(3): 613-8[DOI][PubMed]
  • 26. Shabani Fard A, Shakerian S, Habibi AH, Faraji S. The Effects of 3000 Meters Swimming on Serum Level of Leptin and Glucose Under 2 Different Intensities: Continuous and Intermittent. Jentashapir J Health Res. 2015; 6(6)
  • 27. Blanca AJ, Ruiz-Armenta MV, Zambrano S, Salsoso R, Miguel-Carrasco JL, Fortuno A, et al. Leptin Induces Oxidative Stress Through Activation of NADPH Oxidase in Renal Tubular Cells: Antioxidant Effect of L-Carnitine. J Cell Biochem. 2016; 117(10): 2281-8[DOI][PubMed]
  • 28. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000; 68(4): 437-46[PubMed]
  • 29. Zhaleh M, Panahi M, Ghafurian Broujerdnia M, Ghorbani R, Ahmadi Angali K, Saki G. Role of phosphodiesterase inhibitor Ibudilast in morphine-induced hippocampal injury. J Inj Violence Res. 2014; 6(2): 72-8[DOI][PubMed]
  • 30. Lee YA, Cho EJ, Yokozawa T. Effects of proanthocyanidin preparations on hyperlipidemia and other biomarkers in mouse model of type 2 diabetes. J Agric Food Chem. 2008; 56(17): 7781-9[DOI][PubMed]
  • 31. Arabmoazzen S, Sarkaki A, Saki G, Mirshekar MA. Antidiabetic effect of honey feeding in noise induced hyperglycemic rat: involvement of oxidative stress. Iran J Basic Med Sci. 2015; 18(8): 745-51[PubMed]
  • 32. Kheirollah A, Maghuli A, Dalvand P, Mohaghegh M, Barat T, Aberomand M. Effect of Hexagonal Water on Serum Glucose Level and Lipid Profile in Streptozotocin-Induced Diabetic Rats. Jentashapir J Health Res. 2015; 6(5)
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments