Jentashapir Journal of Health Research

Published by: Kowsar

The Effect of Botulinum Toxin on the Amount of Sialorrhea in Patients With Neurologic Diseases

Seyed Ehsan Mohammadianynejad 1 , * , Davood Kashipazha 1 , Afshin Rezazadeh 1 , Mojtaba Khademian Ghadikolaii 2 , Mehdi Masoudi Moqaddam 2 , Shahram Tarahomi 2 , Fatemeh Sadr 2 , Ali Nakhostin Mortazavi 2 and Seyed Navid Naghibi 1
Authors Information
1 Golestan Hospital, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Neurology Department, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jentashapir Journal of Health Research: April 01, 2015, 6 (2); e29207
  • Published Online: April 25, 2015
  • Article Type: Research Article
  • Received: April 12, 2015
  • Accepted: April 13, 2015
  • DOI: 10.5812/jjhr.6(2)2015.29207

To Cite: Mohammadianynejad S E, Kashipazha D, Rezazadeh A, Khademian Ghadikolaii M, Masoudi Moqaddam M, et al. The Effect of Botulinum Toxin on the Amount of Sialorrhea in Patients With Neurologic Diseases, Jentashapir J Health Res. 2015 ; 6(2):e29207. doi: 10.5812/jjhr.6(2)2015.29207.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Smith RA, Goode RL. Current concepts: sialorrhea. N Engl J Med. 1970; 283(17): 917-8[DOI][PubMed]
  • 2. Lew KM, Younis RT, Lazar RH. The current management of sialorrhea. Ear Nose Throat J. 1991; 70(2): 99-105[PubMed]
  • 3. Breheret R, Bizon A, Jeufroy C, Laccourreye L. Ultrasound-guided botulinum toxin injections for treatment of drooling. Eur Ann Otorhinolaryngol Head Neck Dis. 2011; 128(5): 224-9[DOI][PubMed]
  • 4. Shetty S, Dawes P, Ruske D, Al-qudah M, Lyons B. Botulinum toxin type-A (Botox-A) injections for treatment of sialorrhoea in adults: a New Zealand study. N Z Med J. 2006; 119(1240)[PubMed]
  • 5. Carod Artal FJ. [Treatment of sialorrhoea in neurological diseases with trans-dermic injections of botulinum toxin type A in the parotid glands]. Neurologia. 2003; 18(5): 280-4[PubMed]
  • 6. Thant ZS, Tan EK. Emerging therapeutic applications of botulinum toxin. Med Sci Monit. 2003; 9(2)-8[PubMed]
  • 7. Bushara KO. Sialorrhea in amyotrophic lateral sclerosis: a hypothesis of a new treatment--botulinum toxin A injections of the parotid glands. Med Hypotheses. 1997; 48(4): 337-9[PubMed]
  • 8. Naumann M, Jost W. Botulinum toxin treatment of secretory disorders. Mov Disord. 2004; 19 Suppl 8-41[DOI][PubMed]
  • 9. Costa J, Rocha ML, Ferreira J, Evangelista T, Coelho M, de Carvalho M. Botulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis. J Neurol. 2008; 255(4): 545-50[DOI][PubMed]
  • 10. Gilio F, Iacovelli E, Frasca V, Gabriele M, Giacomelli E, Picchiori F, et al. Botulinum toxin type A for the treatment of sialorrhoea in amyotrophic lateral sclerosis: a clinical and neurophysiological study. Amyotroph Lateral Scler. 2010; 11(4): 359-63[DOI][PubMed]
  • 11. Scheffer AR, Erasmus C, van Hulst K, van Limbeek J, Jongerius PH, van den Hoogen FJ. Efficacy and duration of botulinum toxin treatment for drooling in 131 children. Arch Otolaryngol Head Neck Surg. 2010; 136(9): 873-7[DOI][PubMed]
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