Jentashapir Journal of Health Research

Published by: Kowsar

Effect of Walnut Consumption on Serum Lipid Profiles, High-Sensitivity C-Reactive Protein and Nitric Oxide in Patients With Coronary Artery Disease

Giti Kalantarian 1 , * , Mohsen Rezaei 1 , Shahram Homayonfar 2 and Marzieh Gharibi 3
Authors Information
1 Department of Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
2 Department of Health, Hamadan University of Medical Sciences, Hamadan, IR Iran
3 Department of Biochemistry, Bushehr University of Medical Sciences, Bushehr, IR Iran
Article information
  • Jentashapir Journal of Health Research: February 01, 2015, 6 (1); e27196
  • Published Online: February 10, 2015
  • Article Type: Research Article
  • Received: January 21, 2015
  • Accepted: January 24, 2015
  • DOI: 10.5812/jjhr.27196

To Cite: Kalantarian G, Rezaei M, Homayonfar S, Gharibi M. Effect of Walnut Consumption on Serum Lipid Profiles, High-Sensitivity C-Reactive Protein and Nitric Oxide in Patients With Coronary Artery Disease, Jentashapir J Health Res. 2015 ; 6(1):e27196. doi: 10.5812/jjhr.27196.

Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Nussbaumerová B, Rosolová H, Mayer O, Filipovský J, Cífková R, Bruthans J. Residual cardiovascular risk in patients with stable coronary heart disease over the last 16 years (Czech part of the EUROASPIRE I–IV surveys). Cor Vasa. 2014; 56(2)[DOI]
  • 2. Farkouh ME, Boden WE, Bittner V, Muratov V, Hartigan P, Ogdie M, et al. Risk factor control for coronary artery disease secondary prevention in large randomized trials. J Am Coll Cardiol. 2013; 61(15): 1607-15[DOI][PubMed]
  • 3. Dawar R, Gurtoo A, Singh R. Apolipoprotein A1 gene polymorphism (G-75A and C+83T) in patients with myocardial infarction: a pilot study in a north Indian population. Am J Clin Pathol. 2010; 134(2): 249-55[DOI][PubMed]
  • 4. Gaziano TA, Bitton A, Anand S, Abrahams-Gessel S, Murphy A. Growing epidemic of coronary heart disease in low- and middle-income countries. Curr Probl Cardiol. 2010; 35(2): 72-115[DOI][PubMed]
  • 5. Hatmi ZN, Tahvildari S, Gafarzadeh Motlag A, Sabouri Kashani A. Prevalence of coronary artery disease risk factors in Iran: a population based survey. BMC Cardiovasc Disord. 2007; 7: 32[DOI][PubMed]
  • 6. Devine PJ, Carlson DW, Taylor AJ. Clinical value of carotid intima-media thickness testing. J Nucl Cardiol. 2006; 13(5): 710-8[DOI][PubMed]
  • 7. Almario RU, Vonghavaravat V, Wong R, Kasim-Karakas SE. Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. Am J Clin Nutr. 2001; 74(1): 72-9[PubMed]
  • 8. Zambon D, Sabate J, Munoz S, Campero B, Casals E, Merlos M, et al. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Ann Intern Med. 2000; 132(7): 538-46[PubMed]
  • 9. Wu L, Piotrowski K, Rau T, Waldmann E, Broedl UC, Demmelmair H, et al. Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial. Metabolism. 2014; 63(3): 382-91[DOI][PubMed]
  • 10. Kris-Etherton PM, Zhao G, Binkoski AE, Coval SM, Etherton TD. The effects of nuts on coronary heart disease risk. Nutr Rev. 2001; 59(4): 103-11[PubMed]
  • 11. Fukuda T, Ito H, Yoshida T. Antioxidative polyphenols from walnuts (Juglans regia L.). Phytochem. 2003; 63(7): 795-801[DOI]
  • 12. Hu FB. Plant-based foods and prevention of cardiovascular disease: an overview. Am J Clin Nutr. 2003; 78(3 Suppl): 544S-51S[PubMed]
  • 13. Chisholm A, Mann J, Skeaff M, Frampton C, Sutherland W, Duncan A, et al. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. Eur J Clin Nutr. 1998; 52(1): 12-6[PubMed]
  • 14. Abbey M, Noakes M, Belling GB, Nestel PJ. Partial replacement of saturated fatty acids with almonds or walnuts lowers total plasma cholesterol and low-density-lipoprotein cholesterol. Am J Clin Nutr. 1994; 59(5): 995-9[PubMed]
  • 15. Sabate J, Fraser GE, Burke K, Knutsen SF, Bennett H, Lindsted KD. Effects of walnuts on serum lipid levels and blood pressure in normal men. N Engl J Med. 1993; 328(9): 603-7[DOI][PubMed]
  • 16. Iwamoto M, Imaizumi K, Sato M, Hirooka Y, Sakai K, Takeshita A, et al. Serum lipid profiles in Japanese women and men during consumption of walnuts. Eur J Clin Nutr. 2002; 56(7): 629-37[DOI][PubMed]
  • 17. Zhao G, Etherton TD, Martin KR, West SG, Gillies PJ, Kris-Etherton PM. Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J Nutr. 2004; 134(11): 2991-7[PubMed]
  • 18. Vega-Lopez S, Kaul N, Devaraj S, Cai RY, German B, Jialal I. Supplementation with omega3 polyunsaturated fatty acids and all-rac alpha-tocopherol alone and in combination failed to exert an anti-inflammatory effect in human volunteers:clinical and experimental. Metabolism. 2004; 53(2): 236-40[PubMed]
  • 19. Kris-Etherton PM, Pearson TA, Wan Y, Hargrove RL, Moriarty K, Fishell V, et al. High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am J Clin Nutr. 1999; 70(6): 1009-15[PubMed]
  • 20. Berryman CE, Grieger JA, West SG, Chen CY, Blumberg JB, Rothblat GH, et al. Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia. J Nutr. 2013; 143(6): 788-94[DOI][PubMed]
  • 21. Guevara I, Iwanejko J, Dembinska-Kiec A, Pankiewicz J, Wanat A, Anna P, et al. Determination of nitrite/nitrate in human biological material by the simple Griess reaction. Clin Chim Acta. 1998; 274(2): 177-88[PubMed]
  • 22. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004; 350(14): 1387-97[DOI][PubMed]
  • 23. Munoz S, Merlos M, Zambon D, Rodriguez C, Sabate J, Ros E, et al. Walnut-enriched diet increases the association of LDL from hypercholesterolemic men with human HepG2 cells. J Lipid Res. 2001; 42(12): 2069-76[PubMed]
  • 24. Kinoshita M, Krul ES, Schonfeld G. Modification of the core lipids of low density lipoproteins produces selective alterations in the expression of apoB-100 epitopes. J Lipid Res. 1990; 31(4): 701-8[PubMed]
  • 25. Galeano NF, Milne R, Marcel YL, Walsh MT, Levy E, Ngu'yen TD, et al. Apoprotein B structure and receptor recognition of triglyceride-rich low density lipoprotein (LDL) is modified in small LDL but not in triglyceride-rich LDL of normal size. J Biol Chem. 1994; 269(1): 511-9[PubMed]
  • 26. Kasim-Karakas SE, Herrmann R, Almario R. Effects of omega-3 fatty acids on intravascular lipolysis of very-low-density lipoproteins in humans. Metabolism. 1995; 44(9): 1223-30[PubMed]
  • 27. Harris WS, Lu G, Rambjor GS, Walen AI, Ontko JA, Cheng Q, et al. Influence of n-3 fatty acid supplementation on the endogenous activities of plasma lipases. Am J Clin Nutr. 1997; 66(2): 254-60[PubMed]
  • 28. Simpoulos AP. Hearth effect of w-3 polyunsaturated fatty acid in sea foods. World Rev NUTR Diet. 1991; 66: 590-2
  • 29. Connor WE. Alpha-linolenic acid in health and disease. Am J Clin Nutr. 1999; 69(5): 827-8[PubMed]
  • 30. Mantzioris E, James MJ, Gibson RA, Cleland LG. Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. Am J Clin Nutr. 1994; 59(6): 1304-9[PubMed]
  • 31. Mantzioris E, James MJ, Gibson RA, Cleland LG. Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. Am J Clin Nutr. 1995; 61(2): 320-4[PubMed]
  • 32. Layne KS, Goh YK, Jumpsen JA, Ryan EA, Chow P, Clandinin MT. Normal subjects consuming physiological levels of 18:3(n-3) and 20:5(n-3) from flaxseed or fish oils have characteristic differences in plasma lipid and lipoprotein fatty acid levels. J Nutr. 1996; 126(9): 2130-40[PubMed]
  • 33. de Deckere EA, Korver O, Verschuren PM, Katan MB. Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin. Eur J Clin Nutr. 1998; 52(10): 749-53[PubMed]
  • 34. Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis. 2006; 189(1): 19-30[DOI][PubMed]
  • 35. Lavedrine F, Zmirou D, Ravel A, Balducci F, Alary J. Blood cholesterol and walnut consumption: a cross-sectional survey in France. Prev Med. 1999; 28(4): 333-9[DOI][PubMed]
  • 36. Badimon JJ, Ibanez B. Increasing high-density lipoprotein as a therapeutic target in atherothrombotic disease. Rev Esp Cardiol. 2010; 63(3): 323-33[PubMed]
  • 37. Kasim SE, Stern B, Khilnani S, McLin P, Baciorowski S, Jen KL. Effects of omega-3 fish oils on lipid metabolism, glycemic control, and blood pressure in type II diabetic patients. J Clin Endocrinol Metab. 1988; 67(1): 1-5[DOI][PubMed]
  • 38. Parks JS, Thuren TY, Schmitt JD. Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position. J Lipid Res. 1992; 33(6): 879-87[PubMed]
  • 39. Kris-Etherton PM, Yu-Poth S, Sabate J, Ratcliffe HE, Zhao G, Etherton TD. Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk. Am J Clin Nutr. 1999; 70(3 Suppl): 504S-11S[PubMed]
  • 40. Feldman EB. The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. J Nutr. 2002; 132(5): 1062S-101S[PubMed]
  • 41. Nguyen TT. The cholesterol-lowering action of plant stanol esters. J Nutr. 1999; 129(12): 2109-12[PubMed]
  • 42. Hallikainen MA, Sarkkinen ES, Uusitupa MI. Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner. J Nutr. 2000; 130(4): 767-76[PubMed]
  • 43. Dreher ML, Maher CV, Kearney P. The traditional and emerging role of nuts in healthful diets. Nutr Rev. 1996; 54(8): 241-5[PubMed]
  • 44. Kitts DD. Bioactive substances in food: identification and potential uses. Can J Physiol Pharmacol. 1994; 72(4): 423-34[PubMed]
  • 45. Anderson KJ, Teuber SS, Gobeille A, Cremin P, Waterhouse AL, Steinberg FM. Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. J Nutr. 2001; 131(11): 2837-42[PubMed]
  • 46. Spaccarotella KJ, Kris-Etherton PM, Stone WL, Bagshaw DM, Fishell VK, West SG, et al. The effect of walnut intake on factors related to prostate and vascular health in older men. Nutr J. 2008; 7: 13[DOI][PubMed]
  • 47. Burns-Whitmore B, Haddad E, Sabate J, Rajaram S. Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study. Nutr J. 2014; 13: 29[DOI][PubMed]
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